Science Behind ProFisetin®
Research supporting anti-aging, anti-inflammatory, and brain health benefits
Anti-aging Effects
ProFisetin® acts as a potent senolytic, clearing senescent ("zombie") cells that accumulate with age. A 2018 study in eBioMedicine demonstrated that fisetin reduces senescent cell burden in mice, improving physical function and extending healthspan.
Anti-inflammatory Properties
Inflammatory pathways like NF-κB are inhibited by ProFisetin®. Research in Food & Nutrition Research showed fisetin reduces pro-inflammatory cytokines (TNF-α, IL-6) in human cell cultures, supporting its role in managing chronic inflammation.
Brain Health Support
ProFisetin® crosses the blood-brain barrier and protects neurons via antioxidant and anti-inflammatory mechanisms. A 2020 study in Brain Plast found fisetin improved memory and reduced amyloid-beta accumulation in mouse models of neurodegeneration.
